Adult:
The recommended starting dose of ezetimibe/simvastatin is 10/20 mg/day, but this can be adjusted based on individual patient needs.
Precautions
History of liver disease. Risk of rhabdomyolysis increased in the presence of severe infection, hypotension, major surgical trauma, uncontrolled seizures and severe metabolic, endocrine and electrolyte disorder. Alcoholism; premenarcheal females; child <10 yrs.
Potentially Life-threatening
Adverse Drug Reactions
Headache, nausea, flatulence, heartburn, abdominal pain, diarrhoea or constipation, dysgeusia; myopathy features like myalgia and muscle weakness; serum transaminases and CPK elevations; hypersensitivity; lens opacities; blurring of vision; dizziness; sexual dysfunction; insomnia; depression, upper resp symptoms, dizziness, sinusitis, pharyngitis; chest pain, arthralgia and fatigue.
Adverse Drug Reactions
Severe rhabdomyolysis with acute renal failure.
Interactions
Simvastatin may cause slight elevation of serum digoxin. Cholestyramine and colestipol increase bioavailability of simvastatin. Increase in ezetimibe plasma levels with ciclosporin.
